mid week blues Share definition Flag A healthy bout of sad emotions and feels that occur half way through the week after a weekend of debauchery involving ecstasy. "Hey man, what's wrong?""It's nothing, just come down with the mid week blues after last weekend." mid week blues by eedeee April 7, 2015 0 0 Get merch Get the mid week blues mug. Buy Now — $32.95 See more merch