Knocking one out Share definition Flag A northern slang term for masturbation. To play with oneself, or toss oneself off. "I'd love to come with you, but I'm in the middle of knocking one out" Knocking one out by RichieLeBon March 22, 2012 0 0 Get merch Get the Knocking one out mug. Buy Now — $32.95 See more merch