irregardful Share definition Flag adverb. Full of a lack of regard. A more intense version of regardless. The truest antonym of the nonstandard word irregardless. "Irregardful of common practice, 'irregardful' is just as useful a word as 'irregardless'." irregardful by wizzy0807 May 15, 2013 0 0 Get merch Get the irregardful mug. Buy Now — $32.95 See more merch