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In Knots 

The feeling you get when experiencing a strong emotion such as sadness, frustration or love. A sensation of there being a lump or 'knot' in your throat.
Jamie: OMFG. Michael proposed to me yesterday!
Caroline: Fo real? I can't even!
Jamie: I know! I was so choked up, my throat was literally In Knots!
In Knots by UrbanGh0st July 19, 2016
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knots in my pocket 

The possesion; or holding of a single gram of cocaine.

A very small amount of cocaine, wrapped up in a tight knot.
I got to get rid of these knots in my pocket

dick in a knot 

When a male gets overly anxious about an event. Similar to a woman "getting her panties in a bunch".
John: OMG, this is a complete disaster! What am I going to do?
Jude: Settle down man, don't get your dick in a knot.

Balls In A Knot 

When you get a wedgie so bad that it makes your balls hurt just like they tied in a knot.
Ron: "Dude, I just a major wedgie!"
Denny: "Man, that must have hurt like hell!?"
Ron: "Yah, I pretty much had my balls in a knot!"
Balls In A Knot by ManOfCars June 14, 2009

Twat in a Knot 

when the lips of the female genitalia are so large from getting banged and abused, that she can twist them into a knot. Seen it. It can be done.
The striper at Mel's bachelor party, tied her Twat in a knot!
Twat in a Knot by GoNe1 June 4, 2007

panties in a knot 

Agitated, upset, anxious. Cf. knickers in a twist.
Bitch, so I sold your children for crack! Don't get your panties in a knot!
panties in a knot by Octopod November 7, 2003

Don't get your thong in a knot 

Modern North American derivative of don't get your panties in a bunch or don't get your knickers in a twist. Since the use of thongs as a ladies' undergarment has now widely replaced panties and knickers.
Sit down don't get your thong in a knot