It a mixture of methamphetamine and heroine to be used intravenously. Its name comes from ("Speedball" witch is a mixture of cocaine and heroine).
Mark shoots up a goofball every morning to get his day started, like a drug free person would drink a cup of coffee.
by swayzee84 September 5, 2020
Get the Goofball mug.
When a male has syphilis that has spread to the testicular area, resulting in a gooey discharge.
Her: "Hey darlin, wanna do it tonight?"

Him: "Sorry babe, I got the goofball, and I don't wanna infect you"
by Merpiderp January 24, 2017
Get the Goofball mug.
A lil banana head pony that needs to buck up in life because everything is not just shits and giggles.
by Slothhead February 3, 2010
Get the Goofball mug.
The process of using heroin and methamphetemine (aka meth, crystal meth, ice, etc) simultaneously.

Goofballing is achieved by mixing heroin and meth together in a single rig (syringe), and then slamming (injecting) the mixture into a vein.

Procedurally, goofballing is nearly identical to speedballing, except a goofball mixes heroin & meth, where a speedball mixes heroin and cocaine or crack cocaine.

At the most basic & simplistic level, I explain goofballing as “Heroin AM.”

After doing a goofball one will feel all the euphoric, “feel good” effects of the heroin, a “downer” but none of the usual feelings of drowsiness and tendency to nod that goes along with it. Instead, one will feel a burst of energy & creativity, as well as the ability to stay awake for many days in a row (like it or not), from the addition of methamphetemine, an “upper.”

It makes one feel on top of the world, but beware: add too much meth and instead of feeling on top of the world, it can feel like you’re floating away from the earth, a gnarly feeling to be sure, but also highly disconcerting, to put it lightly!
Goofballing kept us dancing all night long, but despite wearing stilettos, my feet didn’t hurt a bit!
by SnowWhyte June 15, 2019
Get the goofballing mug.
a drug that makes u goof off
goofballs are the best drugs ever
by nunes May 31, 2006
Get the goofballs mug.
Alvin Fayette, Number 1 Goofball
Ed Stapley-Brown, Number 2 Goofball
Matt Isanook, Number 3 Goofball
by Bratley May 22, 2003
Get the Goofball mug.