Speedball- An IV injected mix of heroin & cocaine. This is one of THE most dangerous 2-drug combos known. Speedballing is most often done with the mixture of both drugs in one syringe that's injected. Speedballing not only has a high mortality/death rate, but loss of limb and other problems can arise.

Some inject each drug separately, often a syringe of heroin injected in one arm (or any where else they have a good vein- groin, leg, etc) immediately followed by an injection of cocaine. Sometimes people will shoot (inject) one of the drugs, while having someone else simultaneously shoot the other. Rarely, the Speedball mix is snorted instead of injected but the high is said to be less intense, as IV drugs are usually more potent than snorted drugs, but it's still highly dangerous.

Speedballs are said to cause 1 of the strongest highs... if you live through it. Mixing this upper (cocaine) and downer (heroin) is suppose to counteract some negative effects of the drugs, while also causing an extreme rush and a euphoric high with the "good" effects of both drugs, including the dangerous ones. Contrary to popular belief, Speed, Meth Amphetamines, and other drugs are not used in Speedballs. Historically many used morphine or other opiates instead of the heroin, but most people don't consider this a "true" Speedball now. Some mix benzodiazepines (Xanax, Valium, Klonopin, Ativan, etc) & amphetamines and call it a Speedball, but again this is not considered a true or real Speedball.
John Belushi, River Phoenix, Chris Farley, Jean-Michel Basquiat, MLB Player Ken Caminiti, Pete Farndon, Zac Foley, Chris Kelly from the group "Kris Kross", and Eric Show are just a few from the long list of celebrities who died from doing Speedballs.
by Dr. DontDoIt January 24, 2014
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A mixture of heroin and cocaine administered intravenously. This combination offers the best of both drugs. The lady (coke) gives you a rush of intense euphoria followed by the soporific effects of your boy (heroin), thus effectively eliminating the anxiety and depression that follows when shooting up cocaine by itself.
Me: I've never smoked crack but I've done speedballs.

You: You're fucking kidding me, right? You've shot up coke and smack? I'm breaking up with you, Dumbass.
by kookaburra March 17, 2015
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Injecting heroin and cocaine in the same shot. Intensifies the heroin "flash" or rush of euphoria. For the first 30 second you feel like Tony Montana tit fucking Ashley Pridgen, followed by hours of opiate comfort.
"I just did a speedball a little while ago. Man, lemme tell ya, it felt like titty fucking an angel"
by themanwithnopseudonym September 5, 2011
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Consuming a Taco Bell burrito (which contain heroin) with a large Mountain Dew (which contains dissolved cocaine.)
Yea I'd like a speedball with a side of cheesy fiesta potatoes.
by Rellik Uzi August 18, 2010
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A drinking game involving a min. of 4 players (2 players on each team), 4 cans of beer and a pong ball.
A can of beer is set on each corner of a retangular table. Each team takes a side and cracks their beers (not all the way, only slightly as to ease opening during actual play). Then one person on either team throws the pong ball at the opposing teams beer. If they hit it they have to open their beer all the way and then drink as quickly as possible while the other team hurries to get the ball and return it to the table. When the other team recovers the ball they must return it to the table< touching it to the table, and yelling stop. This in turn signals the opposite team to stop drinking. Now its' the other teams' turn. A team may have more than 2 players if one is unable to run and designates a 'runner' (someone who returns the ball to the table after it is thrown). The object of the game is to be the first team to drink both cans of beer (hence the name "Speedball". You may not share/swap beers with each other or the opposing teams. You may not touch the other teams beer. No one, outside of the players on your team, is allowed to assist in returning the ball to the table.
by SexiLexi1986 January 18, 2011
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1. The awesome mixture of heroin and cocaine for recreational use

2. The greatest sport in the world combining the aspects of soccer and handball with some rules of ultimate frisbee. The game is played on a basketball court with goals on either side (tables, mats, etc) The object of the game is to pass around the ball and score. you can use your hands or feet. When the ball is in your hands, you have to stop moving. When on the ground, you can dribble with your feet. The biggest rule is that the last thing the ball touches before it gets into your hands CANNOT be the ground. (i.e you cant dribble the ball like in basketball. You would have to kick it up to yourself to get it in your hands off he ground) Score with hands = 1pt, Feet= 2pts, head = 3pts...PLAY TO WIN
1. Guy 1: Dude Im bored as hell

Guy 2: Wanna go do some speedball?

Guy 1: Yea, but only if its a 65:35 heroin

2. Person 1: Hmm i want to play soccer, but then I also want to use my hands like in handball, but then I'd like to somehow incorporate the rules of ultimate frisbee...Too bad there is no sport like that.

Person 2: Are you fucking retarded? Did you not read the definition above? Its called speedball dumbass
by the crimson chinn August 17, 2009
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One of wakeboarding's most revered maneuvers, invented by Darin Shapiro. The Speedball is a heelside double front flip. Normally done off of the Double Up, the rider rotates twice before landing.
If Shapiro hits the Speedball, kiss this competition goodbye.
by Crew Middle Fork September 26, 2004
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