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Speedball- An IV injected mix of heroin & cocaine. This is one of THE most dangerous 2-drug combos known. Speedballing is most often done with the mixture of both drugs in one syringe that's injected. Speedballing not only has a high mortality/death rate, but loss of limb and other problems can arise.

Some inject each drug separately, often a syringe of heroin injected in one arm (or any where else they have a good vein- groin, leg, etc) immediately followed by an injection of cocaine. Sometimes people will shoot (inject) one of the drugs, while having someone else simultaneously shoot the other. Rarely, the Speedball mix is snorted instead of injected but the high is said to be less intense, as IV drugs are usually more potent than snorted drugs, but it's still highly dangerous.

Speedballs are said to cause 1 of the strongest highs... if you live through it. Mixing this upper (cocaine) and downer (heroin) is suppose to counteract some negative effects of the drugs, while also causing an extreme rush and a euphoric high with the "good" effects of both drugs, including the dangerous ones. Contrary to popular belief, Speed, Meth Amphetamines, and other drugs are not used in Speedballs. Historically many used morphine or other opiates instead of the heroin, but most people don't consider this a "true" Speedball now. Some mix benzodiazepines (Xanax, Valium, Klonopin, Ativan, etc) & amphetamines and call it a Speedball, but again this is not considered a true or real Speedball.
John Belushi, River Phoenix, Chris Farley, Jean-Michel Basquiat, MLB Player Ken Caminiti, Pete Farndon, Zac Foley, Chris Kelly from the group "Kris Kross", and Eric Show are just a few from the long list of celebrities who died from doing Speedballs.
by Dr. DontDoIt January 24, 2014
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2
The combination of the narcotic heroin and stimulant cocaine mixed together and injected together in a single shot. When administered IV, the speedball produces the best rush/high in the world of drugs and is the most deadly of procedures as far as getting loaded. Highly addictive. Beyond destructive. Will bring any addict to their knees. It will call you and lure you, lie to you and kill you. Like alcohol and pills as well. This is the worst though. That is why it is the best.
"Man, my habit and tollerance were getting out of control. I was shooting about eight to ten speedballs a day just to stay high and not get sick."
by Martin Throttle June 29, 2006
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3
A mixture of heroin and cocaine administered intravenously. This combination offers the best of both drugs. The lady (coke) gives you a rush of intense euphoria followed by the soporific effects of your boy (heroin), thus effectively eliminating the anxiety and depression that follows when shooting up cocaine by itself.
Me: I've never smoked crack but I've done speedballs.

You: You're fucking kidding me, right? You've shot up coke and smack? I'm breaking up with you, Dumbass.
by kookaburra March 17, 2015
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4
It's a mix of heroin and cocaine and is ussually injected
you havent tried nothin until youve had a speed ball
by Kari January 01, 2004
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5
To combine cocaine and heroin in one douse, or a drug in it's own that is a combination of cocaine and heroin, so the desired user can take it at once. Some have termed it a more organized version of speed, which is why it is called "speedball", because it's been packed together organized, with actual care, like it takes care to make a ball.
Most people prefer Speed to Speedball, unless they mistake them."
by Bowman June 16, 2002
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6
A mixture of cocaine and heroin injected into oneself. Killed the legendary John Belushi, R.I.P.
After a night of partying with Robert De Niro and Robin Williams, John Belushi injected a speedball directly into one of his veins. IT KILLED HIM. (True story)
by Stick With Weed February 19, 2007
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