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Formerly and through the late 1980s anf 1990s, slang for barbiturates. Later expanded in common vernacular to include benzodiazepines (such as Xanax and Valium).

Commonly used today to describe the recreational combination and use of heroin and methamphetamine via IV injection.
When cooking up a hit of dope, "I got a couple points of shards, too; you wanna slam a goofball?"
by Fuckingspiders October 03, 2016
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Slang term for Barbiturates.
Barbiturates, such as phenobarbital and secobarbital, are any of various derivatives of barbituric acid used especially as sedatives, hypnotics, and antispasmodics.
Barbiturates have largely been supplanted by Benzodiazepines (such as Valium, Xanax) due to addictive potential, extensive abuse, and severe withdrawal syndromes.
I need to hook up some goof balls, to help me kick heroin
by narkologik May 21, 2005
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A term of endearment between online friends, similar to "buddy", "bro", etc. Tends to be used when one friend does something silly or funny.
Used mainly in America by those unfamiliar with the derogative form of the word.

Also used: goof, goofball, goofy
"You're such a goofball :P"
"You're so goofy"
by BohemianGoof February 10, 2012
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Someone who is silly or stupid. Also looks silly or stupid.

Opposite of a chill bro.

People generally laugh at them than with them.
A: Do you know Declan?
B: Nah, I don't.
A: You know, the massive goofball?
B: Oh, yep! He's the king of goofballs.
by Double Denim Ranga August 02, 2010
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A term often used to describe a pretty girl when she does something adorable. Despite her sassy demeanor that often produces caustic one-liners that can put any cocky son of a bitch in his/her place, she has enough spark to attract a long list of Starbucks’ lovers.
Jermaine: Homie, I wish I had a goofball to brighten up maaaa lyfe!
D’Shawn: Son, you know Sharon’s single, nomsayin’ B?
Jermaine: Daaaaaaaaaaaayummmmm, she a real goofball, Imma get those digits.
by goofbaws February 07, 2015
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