An extreme disappointment, who's foolish mistakes trace back to before they were were even born.
I would have never screwed your mother in the first place, if I had known what kind of prenatal fuckup you'd be.
by pierski June 15, 2009
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Notre Dame on the 15th of April 2019. Another synonym for this would also be Melted Bible.
I worked at Notre Dame under the French Fuckup
by T0b14s October 20, 2019
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When you're watching porn, however pre orgasim, your hand either changes or loses grip or the video changes to a shit part. After orgasim you regret that you did so as you feel you have wasted an opportunity.
I hate it when you Wank fuckup, it's so annoying!
by i'mlikeheywhatsuphello October 2, 2015
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A co-worker or other company contact who is completely useless.
"Dammit that new PR guy is a fuckupational hazard!"
by nonplussed February 23, 2017
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When you fuck up so bad you have to get government help before you reveal the total sum of fuck up
The epic japan earthquake tsunami fukushima fuckup of 2011
by yaktownwelder March 15, 2011
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When your comuppance is a fuck up.

The bad karma you receive after you fuck up something for somebody else.
This generally occurs when the other party involved wishes ill intentions on you.
Julias Caesar: "To: Brute, your fuckup-ance will come".
by Damiano DeMonte October 21, 2007
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basically when you had fucked up but to a much great extent.
Person 1: Dude my dog shitted all over the neighbor's yard
Person 2: now that's a colossal fuckup
by KarateMachinery August 16, 2018
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