For sure, my nigga. Should only be used by a black person, to a black person - unless you want your ass kizzled. Variations acceptable for use by whitey include:

fo' shizzle my sizzle = For sure, my sister.
fo' shizzle my bizzle = For sure, my brother.
Yes sir, Suge sir. Right away sir. = Please Suge, don't kill me.
Whitey 1: Hey man, are you going to the club tonight?
Whitey 2: Fo' shizzle, my bizzle. Right after I watch the game on my televizzle.
Whitey 1: Sorry Suge sir, don't kill him.
by udc March 12, 2003
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Archaic phrase used by African American slaves since the 17th century. A corruption of 'For shine his hall, my knees ill' it was used as a greeting by slaves who had to polish the floors of colonial mansions. Later became an unrelated greeting.
'Missie, missie - yo massah done made me polish dat whole corridor, an it done made my knees hurt terrible - fo' shizzle ma nizzle, an no mistake!' from 'Gone With The Wind' by Margaret Mitchell.
by Anonymous June 26, 2003
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fo shizzle my nizzle, or fo hizzle my wizzle, tranlates to: for sure, my nigger OR for sure my white-nigger. its mostly used by snoop dogg, dr dre, and eminem.
jay-z: "fo shizzle my nizzle used to sribble down in v.a"
by niggerina_hannah August 19, 2006
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A slightly aborted version of a declined McDonald's slogan:
Hamburglar: "Come robble my knobble."
by WASTELY March 16, 2003
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The mean of Fo Shizzle My Nizzle is For sure, my nigger. often used when a Gangster or some sort of black person (or in some rare cases a white person) says it to his friends to make him seem cool or "gangster"
Rick: you sup joe
Joe: nutt'n much you?
Rick: same.... Oh shit its billy i hate that fag...
Billy: Yo Fo shizzle my nizzle dog
by Nomad guy February 1, 2009
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The act of giving a shizzle on a nizzle this will often take place in the back of starbucks
Girl 1: Sup jack, you should fo shizzle my nizzle
Guy 1: Ill be down fo shizzlin ya nizzlin
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