dope sick nasty Share definition Flag When something is so fucking awesome that it is at the same time dope sick AND nasty. "Dude did you see that crazy trick i just did?" "Yeah man, that was dope sick nasty!" dope sick nasty by Jovomo March 6, 2010 0 0 Get merch Get the dope sick nasty mug. Buy Now — $32.95 See more merch