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street term for Methadone pills, a downer / pain reliever often prescribed to recovering heroine addicts.

its often sold on the street and abused for a ballin high...
A: bro i just railed 2 domes...now im drinking

B: thats fuckin dumb...

A. ZZZZ....
domes by wrather June 25, 2009
" Just got back from picking up some domes."
" Man, did you get some domes for tonight?"
Domes by KingKeeler September 18, 2013
umm no to the other definition -- its actually a word for condoms that weird ppl use
u got domes
strawberry flava
safe sex kids ;)
domes by Jordz June 7, 2005
"I just picked up an ounce of domes. Let's go camping."
domes by Dr. Todd Reezee February 4, 2009
The act of working domes in Halo 3.
"Hey guys let's hop on the sticks and work some domes."
"I just worked that guy's dome."
"Did you see me just work that guy's dome"
"Domes..?"
"Alright guys, we're gonna smoke a bleezy then work some domes"
domes by Meezy18 March 28, 2008
When talking about a person or a group of people
Slide thru I’m here at the crib with a couple of domes”
Domes by sllabymelgrag September 1, 2019