To miss an opportunity by a wide margin. By failing to act/speak/do something promptly, the window of opportunity closed.
GM wants to get concessions from the UAW in order to avoid going bankrupt, but that bus left a long time ago.
by Jim K July 25, 2008

by Jenn August 17, 2004

Dude One: Hey, leave Nick alone, man. He just found out that he's failing all his classes, his girlfriend's been cheating on him, and all his friends just went on a road trip to Vegas without him! He's been totally bus left!
Dude Two: damn!
Dude Two: damn!
by Auduck October 15, 2005

by Shawtzie October 29, 2005

My bus left me high and dry, hand me another.
The bus just left the building.
My bus just crashed.
I just missed the bus.
The bus just left the building.
My bus just crashed.
I just missed the bus.
by AngieC October 16, 2005

by want2befree13 December 28, 2005
