To have your entry in an office pool or bracket, particularly for the NCAA men's basketball tournament, become worthless because one of your teams lost much earlier than anticipated.
That Georgetown game completely bracketfucked me. I had them winning the whole tournament, so I have no chance of winning money now.
When you have had enough of everyones shit so you just want to lie in bed with your blanket over you face to the point where you're suffocating but you can still kinda breathe.