To completely dumbfound, confuse, or otherwise
render speechless by either asking a
question or stating something beyond their
intelligence.
Toni:The mechanism of endocannabinoid synaptic transmission is believed to occur as follows: first, transmission of the excitatory neurotransmitter glutamate causes an influx of calcium ions into the post-synaptic neuron.
Guy: ummm... what? (
Toni baffled Guy)