by nellaws September 24, 2003

What is up my brother?
by Anonymous August 18, 2003

Asks what another has his attention on. What is he thinking about or busy with? "Up" in this case is using a slang definition from around the 1930s meaning: occupied with, busy with.
This question is often used to start conversations with.
This question is often used to start conversations with.
When I called my friend he didn't seem happy so I asked him "What is up?". He said he was having trouble with his girl.
by Scottmana September 29, 2007

by JayXSta December 15, 2004

by cherrypicker March 17, 2007

This is a combination of "what's goin on?" and "what's up?". I said this accidently the first time I talked to this guy on the phone. I was trying to be cool and confident but inside I was nervous as hell! LOL
by beezolini March 08, 2009

What me up means, you asked someone to update or brief you about the current affairs or relevant local or global affairs.
by Irma boy July 21, 2019
