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An popular example of shipping in My Little Pony: Friendship is Magic, in which Twilight Sparkle and The Great and Powerful Trixie are paired together.

Its extremely high profile is due to its main proponent, Sethisto, running the central Friendship is Magic fansite, Equestria Daily.
"Twilight galloped away, tears welling in her eyes, running for the one pony whom she truly could trust. The door of Trixie's caravan slammed open, and the blue unicorn looked up in surprise; but a glance at Twilight's face explained everything. Without saying a word, she reached a hoof up to Twilight's neck and pulled her close. As the storm raged on outside, Twilight, at last, felt safe."

"Awesome story! I love Twixie!"
Twixie by RatManBatMan August 23, 2011
A term used to define 2 persons who have something in common
We're both stalkers! We're stalker TWINIES.
Twinies by Bribri89 April 25, 2009

trixiesexual 

hi paul i know your here :)
"what's ur sexuality"
"i like trixie,, so im a trixiesexual"
"what the fuck"
trixiesexual by uwusussybakarrr October 19, 2021

Twigiest 

Very skinny
She is the twigiest of all twigs.
Twigiest by jay1994 June 16, 2017

Twixties 

(Noun) Used to highlight the parallels of events and overarching themes between the 2020s and 1960s — social order, government power, polarized beliefs, etc.
“A generation gap is appearing again. This is just life in the Twixties”
Twixties by GraniteRealness October 9, 2021
The most gamer gamer on planet earth who is super hot and amazing. (you should simp for her)
"Man, Twixie sure is hot. I think I will ask Twixie out on a date."
"B-but I like Twixie!"
Twixie by Twoxer Geaminege August 20, 2021