Syphilis Juice Share definition Flag The most dangerous drug in the universe!!! Has the ability to turn people into complete idiots... Dude, stop sippin on that syphilis juice... You're in a whole different, very strange world... But you're acting like an idiot in this world. Syphilis Juice by GhostInAShell April 29, 2022 Get the Syphilis Juice mug.