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To slay a Moron, Through spoken word or Physical action.
Damn bro you gonna let him slaymoe you like that?
Slaymoe by SLaYMoE December 9, 2008
Related Words

Slaymode 

Slaymode is a term used to describe the state of mind that occurs whenever a professional gamer starts to play very seriously and annihilates all his opponents.
Fan 1: Did Insert pro-gamer here win that competition?

Fan 2: Yeah, he was in slaymode
Slaymode by Azniac September 22, 2012

slayhoed 

To totally, utterly, and unequivocally decimate an opponent or person
That Noob jungle Vlad got slayhoed by warwick.
slayhoed by DoctorKpuffy March 6, 2015