1) a reaction to a really shocking and important story.
2) a way to say "that sucks, i'm sorry" after someone has told you something truly shitteous that happened to them recently.
3) what a father replies to a son when the son asks what is that in the toilet.
1)
kid: "i smoked soo much weed and then ate a pie out of the garbage..."
kids friend: "SHIT, SON!!!!!"

2)
guy #1: "i've had such an awful day. first, my pet fish died. then my girlfriend broke up with me. and now I found out that I only have 2 days to live.
guy #2: "shit, son."

3)
little boy: "daddy, what is that brown stuff in the toilet?"
father: "shit, son."
by Numba123 October 12, 2009
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Usually said in disbelief, shock, or amazment.
Shit son! I didnt know we get ALL 100 porn channels!!!
by Bill Kiniry February 20, 2006
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a general exclamation used in any situation, good or bad
shit son, that was tight
shit son! we almost died!
by Bryan=the shit March 20, 2006
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a phrase used when the sayer of the phrase wishes to express knowledge of an aforementioned statement, regardless of the context.
Person A (To a Metallica Fan): You know nothing about the lyrical stylings and intricacies of Ben Folds.
Person B: No shit, son.

Person A: I just realized the clouds are blue.
Person B: No shit, son.
by khrushchev April 18, 2007
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Something to say when ur about to run.
shit son its wayne brady
by Chr1s LooHAN! September 25, 2005
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