A relatively new underground drug which is the combination of shard mollie and mescaline.
"Hey you guys want some sassafras?"

"Hell yeah i love rollin with mescaline"
by TheloneusKool April 15, 2009
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Having enormous amounts of random useless knowledge. See also Bill Dawson.
Bill sure showed a lot of sassafras to pull that one off...
by akak1701 November 5, 2004
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this word that stewie claims is real that TOTALLY IS NOT A REAL WORD.
blah blah sassafras
oh yeah cus googlydeblokenshiemid

what that isnt a word?
yeah well neithers SASSAFRAS
by googlydebloknshiem July 26, 2010
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A term used in the American Northeast to describe human hair, usually red, that closely resembles a lion's mane. Usually unruly and untamed.
"Caitlin looks like a lion with hair like that." -girl #1

"Well, obviously, it's sassafras. Of course it makes her look like a lion!" -girl #2
by Tiffz! July 9, 2009
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When a guy or girl experiences multiple, intense orgasms by having sex several times in a short period of time.
I went away with my girlfriend for the night and holy shit it was such a sassafras we're both still aching days later.
by gatocurioso January 11, 2019
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A whore that resides within the domain of Corr Hall and is very sassy to the best person in the world.
"Tiff, you were a total sassafras when I saw you earlier."

or

"Tiff, why are you such a sassafras?"
by The Offended (DA) December 4, 2009
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