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Sassafras 

Slang for Methylenedioxyamphetamine or MDA, a psychedelic stimulant that can be classified as both a phenethylamine and an amphetamine. This term is popular among fans of jam bands and probably originated somewhere within the psychedelic music scene. The term is also used to distinguish powdered MDA from powdered MDMA, often referred to as "molly."
Head A: I ran into some righteous Sassafras at Rothbury, the campgrounds were full of it!

Head B: Heady.
Sassafras by ramlbin' rose August 2, 2009
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sassafras 

1. A feisty girl. 2. One who sasses.
"Don't be such sassafras when I ask you to do something."
sassafras by Freckleface December 28, 2007

sassafras 

a tree or the root of this tree that is often used to make GOOD root beer.
you: hey, what's in Hansen's creamy root beer?
me: sassafras and some stuff.
sassafras by Lo Beedle January 26, 2004

Sassafras 

(n)--although the denotation specifies this as a tree, many have come to associate the connotation of "sassafras" with a term defining heavy amounts of sarcasm. Drawn from the root word, "sass," sassafras can be synonymical with sardonicism, facetiousness, witticism, or any other form of smarmy behavior.
Brandon could not take Spencer's unusual amount of sassafras, so he falcon punched her in the face. Twice.

If you don't quit that sassafras of yours, I will waslap you in the face. Again.
Sassafras by Waspence December 8, 2010

sassafras 

derived from the word sassy. the act of being a smartass, back-talking, rude and disrespectful; impudent.
you: isn't he a nice guy?
me: yeah, if you like balding purtentious assholes!
you: wow, your being a sassafras.
sassafras by jpjearz August 11, 2006

sassafras 

sassafras(;
you can sip it in the morning, sip it in the evening, even a quarter after threee!

Cuz i like sassafras!
You like sassafras!
We like sassafras TEAAAAAAAAAAA!
;D

Sassafras 

A term used to describe the act of sarcasm or rude, back-talking behavior. It is typically a word that most adults find appropriate in defense to a younger person. Adults were likely called the term in their younger days and despise ever being called that again. They will therefore call someone the name to feel superior and have the upper hand.
Adult: You need to go take a five minute time-out in your room.

Kid: What for? I didn't do anything!

Adult: Well sure you did! Now you're just being a sassafras!

Kid: FINE!!!
Sassafras by Raine tones February 8, 2012