sanctum Santorum 

1. the anus, that holiest of holes, a place that only the privileged may enter
2. the anus when smeared with santorum, a term popularized by sex columnist Dan Savage and his readers.
3. the home of Senator Rick Santorum (R-Pa.)

I got drunk last night and got pegged in my sanctum santorum.

sanctum Santorum by Mitchell April 24, 2004

Sanctum Santorum 

Notably different than 'Sanctum Sanctorum'.

The classical Latin phrase 'Sanctum Sanctorum' means literally "Holy of Holies." It was originally applied in a religious context to the most sacred place within a sacred building, such as a temple. However, in common usage can also be applied to mean any reserved, private, or much-valued place.

'Sanctum Santorum' has two meanings:

1.) Holy Shit
2.) That most precious and sacred place in your body where one may find Santorum

You are told by a co-worker on a Monday morning that your boss was arrested over the weekend for man-on-dog sex. The only appropriate response: "Sanctum Santorum!!"

You are disapprovingly describing an acquaintance who acts like a slut. "He doesn't treat his body like a temple. His Sanctum Santorum is anyone's for the asking."

Sanctum Santorum by PeterBenFido March 13, 2011