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Safe as fuck 

Perverted from the British slang safe, which meant everything from cool to "hello", depending upon context, "safe as fuck" is used to refer to being high, low, or stoned in any context, whether intentionally or not. There is an aspect of the term that is connected to just how out-of-touch the person using the term is; generally, if someone is high enough to use the term, they are only safe in their own minds and should not drive, operate machinery, etc.
Person 1: "Mate, are you fuckin' high?"
Person 2: "Safe as fuck, man, safe as FUCK."

Safe as Fuck 

Used by the ever growing Chav culture in England to describe an object, event or doing of something to be realy great. Often spelt Safe as, or Safe as fuk.
Alternatives are:

Off the box
Mint
cushtie
Ya m8 dats safe as fuck!
Leah bond aint safe as fuk mush!
Safe as Fuck by Cribbo December 28, 2005

safe as fuck 

use also as a greeting
guy 1, safe?

guy 2, safe as fuck bruv init :)
safe as fuck by EQ January 21, 2008

fucking safe as fuck

something really, really, really, really, really, really, really, really, really, really, really, really, good. used in general conversation - invented by the goldie lookin' chain
fucking safe as fuck by Milo man February 9, 2004