Ruff Buff Share definition Flag a name refering to the ghettos of Buffalo, NY. specifically: the East Side, the West Side, Riverside, Black Rock, the Old First Ward, South Park, and Seneca "I'm from the Ruff Buff, East Side" Ruff Buff by "Sniper" November 29, 2007 0 0 Get merch Get the Ruff Buff mug. Buy Now — $32.95 See more merch