the act of getting "dome" (aka head, fellatio, blowjob, etc.) from a girl who you do not know (generally a promiscuous female who has self worth issues and has to prove to herself she is worth anything).
Hence the "random" part of ranDOME.

The Nussy, or the “nose pussy”, if you will, was discovered during the corona virus pandemic of 2020. People that had to be tested for Covid-19 had to have their nose swabbed right where the brain connects, which often led to people rolling back their eyes and gagging.

A nose-swab-fetish developed from this, because we, as humans, ruin everything.

Getting head (dome) from a totally random girl you don't know.

for some reason stupid people decide to spell random with a 'e' thus making randome therefore proving that the person(s)are/is very stupid

the act of giving random head

The act of getting dome from a random girl

(Pronounced Ran - dom - may)

Randome is a term used to describe the random appearance of manga-inspired or manga art that would show up as a result of an unrelated Google Images search. Say, for instance, you googled 'Team Fortress 2'. Team Fortress 2 is a Hat Simulator that has no basis or any relativity with Japanese art whatsoever. However, anime-inspired images of the characters appear regardless. Same goes for just about anything else, including a search of the word 'survivalist'.

While techically considered manga, 'randome' is the more accepted term because it is easier to say and it is derived from the words 'random' and 'anime'.