Pyst off Share definition Flag Very angry at somebody or something; it means the same (and is pronounced the same) as "pissed off". Man I was so pyst off at that bunghole for stealing my towels out of the dryer at the laundromat!!! Pyst off by Telephony September 23, 2010 0 0 Get merch Get the Pyst off mug. Buy Now — $32.95 See more merch
