Pill Sauce Share definition Flag If someone calls you pill sauce, it means that your pill (head) is too sloppy and your head is really unattractive. "Guys, look over there, it's Jon!" said Ed "I think he's a pill sauce!" replied Matt Pill Sauce by ralphos101 September 15, 2014 0 0 Get merch Get the Pill Sauce mug. Buy Now — $32.95 See more merch