A term used in football when a player of the defensive team intercepts the ball thrown by the quarterback of the offensive team and runs it back into the end zone for a 6 point touchdown. "Pick" is open to interpretation but is basically used for when the defensive player grabs the ball. The "six" is used to describe the six points earned from the touchdown.
by Brit Morgan October 22, 2013
SPORTS FAN 1:"Did you see Ed Reeds' PICK SIX off Tom Brady last week?"
Sports Fan 2:"Hell yeah!The Ravens'season is over.Might as well play spoiler."
Sports Fan 2:"Hell yeah!The Ravens'season is over.Might as well play spoiler."
by L.MARTIN November 17, 2005
An interception returned for a touchdown in football. Basically what Aqib Talib would do every season when he’s done with Michael Crabtree’s chain.
Fan 1: Dude did you see Aqib Talib against the Raiders?
Fan 2: Oh yeah, Crabtree probably has to spend a lot of racks on a new chain.
Fan 1: No, I mean that nasty pick six.
Fan 2: Oh yeah, Crabtree probably has to spend a lot of racks on a new chain.
Fan 1: No, I mean that nasty pick six.
by Maffs January 29, 2018
McNamara's about to pick six! Nick brought Nancy home but when Mc told her that Nick has the hiv, she suddenly wanted a little Irish in her.
by The Dankl March 25, 2008
by exthboxth November 05, 2010