One-Eyed Bill Share definition Flag When a man is on top of a woman having sex and is so drunk that only one eye is open. I was having sex with this dude last night and he was totally doing a one-eyed Bill One-Eyed Bill by Jem Bot August 19, 2009 0 0 Get merch Get the One-Eyed Bill mug. Buy Now — $32.95 See more merch