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Loosely meaning "over my dead homie's grave" also used as "for sure". Acronym of the names: Nappy, Eddie, Phil, Harold, and Slick.
Nephs, you ain't gettin' through this door.

Yo, did you just see that?
Nephs.
nephs by SirWraith May 5, 2004
"Nephs" means "on my dead homies' grave"
Nephs, those dubs are tight.
I had to kill that foo', nephs.
nephs by Jigga Man January 6, 2003
Term meaning "On my dead homie's grave." Slang emphasizing or questioning the validity of a statement.
Nephs, did you just see that?
Nephs I just gave you 20 bucks.
Nephs those rims are tight.
nephs by J-Ryan January 11, 2003
Some of the Nephs (Dead Homies from the Hill District in Pittsburgh)

Black Boo, Tizzy, D, Ike, Bugaloo, Eddie, Harold, Phil, Delaney, Darius, Rodi Booth, Shitty I (Clarence), Ty Edwards, Kendre (Mad Circle), K-Dog, Dale Williams,
On the Nephs
Nephs by Nova25 December 23, 2009
-i swear yo

(an acronym in remembrance of legendary dead homies)
Ayo, on the nephs i busted a cap on him ike.
nephs by spoleze February 15, 2003
seriously, no lie, on everything you love, on ya dead homie
Nephs I saw her last night with some other nigga, Nepphs I did.
nephs by Tiffany November 9, 2003