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It means Hey You.
It is mainly used when addressing an individual in any given situation to get his or her attention.
Ayo! What time is it?
Ayo, Can I talk to you for a minute?
by E520 October 22, 2003
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a streamlined fusion of the salutation "hey, yo" that goes over extremely well with the modern urban entrepreneur.
"ayo, slim, whatcha'll be on?"
by sinicalypse May 04, 2003
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Ayo is an amazing he has an amazing heart that can heal any wounds. He is a person that will do anything to help you and bring you back on track. He may not be the Handsome person everyone thinks of but he has a handsome heart. He also could look weak but he his a strong person emotionally and Physically so don’t mess with him he comes from a rich family and normally a person from Africa. In Yoruba his name means joy. And he definitely brings joy to peoples hearts and lives. Ayo is definitely a person you can confine in. He will have your best interest in heart.
Person 1: Hey who is that?
Person 2: That’s Ayo he is amazing

Person 1: You have to introduce me
by Darkphantom January 02, 2019
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a response for a very suspect or homosexual comment.
Dude 1: That's a big bulge in your pants, what is it?

Dude 2: AYOOOOOOO!!!!!!!!!!!!!
by Sosa Ave July 13, 2008
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This is a Nigerian name of the Yoruba dialect which means 'Joy'. It can be combined with other names.
e.g. Ayodele meaning Joy (Ayo) has come/arrived home (Dele)
by nun ur biznaess September 03, 2006
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