McVacuate Share definition Flag When you are hungover, eat McDonalds, and the food quickly evacuates your body, either through the mouth or through the rectum. "Ugh pull over I gotta McVacuate.""The chicken nuggets have McVacuated the premises." McVacuate by MaggieMae33 September 16, 2009 0 0 Get merch Get the McVacuate mug. Buy Now — $32.95 See more merch