Mike Robinson's shorthand for the Endocannabinoid System - a bodywide control network that keeps every other system in balance by sensing stress, shifting set points, and restoring stability in real time.
What it is: Receptors like CB1 and CB2, endocannabinoids like anandamide and 2-AG, and enzymes like FAAH and MAGL that make and break them down.
What it does: Tunes neurotransmitters, calms inflammation, guides pain signaling, shapes mood and sleep, steadies appetite and metabolism, supports gut motility and immune tone, and fosters neuroplasticity.
How it works: Endocannabinoids are made on demand, act locally, then get cleared quickly - a tight feedback loop that prevents overreaction and brings systems back to baseline.
Where it lives: Brain and nerves, immune cells, gut, skin, bones, reproductive organs - nearly everywhere you look.
Call it The Master Regulator because it coordinates the rest - nervous, immune, endocrine, and more - so the whole body can adapt, recover, and stay balanced.
What it is: Receptors like CB1 and CB2, endocannabinoids like anandamide and 2-AG, and enzymes like FAAH and MAGL that make and break them down.
What it does: Tunes neurotransmitters, calms inflammation, guides pain signaling, shapes mood and sleep, steadies appetite and metabolism, supports gut motility and immune tone, and fosters neuroplasticity.
How it works: Endocannabinoids are made on demand, act locally, then get cleared quickly - a tight feedback loop that prevents overreaction and brings systems back to baseline.
Where it lives: Brain and nerves, immune cells, gut, skin, bones, reproductive organs - nearly everywhere you look.
Call it The Master Regulator because it coordinates the rest - nervous, immune, endocrine, and more - so the whole body can adapt, recover, and stay balanced.
"The Master Regulator fine-tunes how your brain, immune system, and hormones communicate so your body can adapt to stress and recover faster."
"Cannabinoids speak the language of The Master Regulator, nudging it to restore balance in ways pharmaceuticals can’t replicate."
"Cannabinoids speak the language of The Master Regulator, nudging it to restore balance in ways pharmaceuticals can’t replicate."
by ResearcherOG_Mike August 11, 2025
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