A Spanish expression translated litterally as "Oh mother!" but it have several meanings like Oh My God, Holy shit, oh crap, and anything that makes you look like WTF.
*F1 2010 German GP: La Sexta*

Smedley: "Ok.. so.. Fernando... is faster... than you... can you confirm you understood that message?"

Mark Gene: "..... Madre mia!!..."
by bullcrap December 5, 2010
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