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I don't fuck with you 

Wanting nothing to do with someone, whether as a friend/acquaintance or more. Can be abbreviated as "idfwy" or "idfwu". Gained popularity from Big Sean's song. Not to be confused with the sexual meaning of "fucking someone".
Kacey: Hey why don't we invite Lisa to the party?
Marissa: Hell no. I don't fuck with her, she's annoying

Jason: Hey baby I miss you, let's get back together
Kacey: No thanks, I don't fuck with you
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I don't fuck with you 

A song made by Big Sean. It is literally a song about not caring.

I'm the one you don't fuck with 

A phrase you use when introducing yourself, a phrase that is shrouded in mystery and makes you look like a total badass.
Guy #1: Hey, who is that guy in the dark corner?

Guy #2: I don't know, lets ask him.

(Walk up to the badass)

Guy #1: Who are you?

Badass: I'm the one you don't fuck with...

Guy #1 & #2: O.O