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Wanting nothing to do with someone, whether as a friend/acquaintance or more. Can be abbreviated as "idfwy" or "idfwu". Gained popularity from Big Sean's song. Not to be confused with the sexual meaning of "fucking someone".
Kacey: Hey why don't we invite Lisa to the party?
Marissa: Hell no. I don't fuck with her, she's annoying

Jason: Hey baby I miss you, let's get back together
Kacey: No thanks, I don't fuck with you
by LeiDomingues July 31, 2016
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A song made by Big Sean. It is literally a song about not caring.
"I don't fuck with you, you big dumb dumb."
by GameCheater803 April 01, 2016
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