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guinea pig of one's own demise 

what someone becomes when he or she goes out on a limb to try something new or risky and ends up having his or her plan fail completely.
Theorizing that the more I studied, the worse I do on tests, I didn't study for my comp sci test and I failed. I was the guinea pig of my own demise.

In Spider-man, when Norman Osborne conducted experiments on himself that lead to his insanity and death, he was the guinea pig of his own demise.

(variations of "guinea pig of one's own demise")
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guinea stompers 

Shoes made in Italy; especially, but not limited to, the designer brand name products. The attachment of metal tap plates on the heels and/or toes may also qualify the shoes whatever the country of manufacture.
You can't dress like Guido without your guinea stompers.
guinea stompers by casual observer12 February 10, 2012

guinea stinker 

A big, fat, smelly cigar favored by older Italian-American men.
Look at that guinea stinker Tony has in his mouth.

guinea sack 

a small amount of high caliber marijuana, roughly equivelant to a dime bag"
Mike: "I only had $20.00, so I just bought a guinea sack."
guinea sack by Fast Willie27 June 18, 2006

guinea spike 

the hairdo sported by most young italian men. It is characterized by a "fade" up to the ears, then 3-5 inch hair on the top of their head, dramatically spiked facing backward
"The Gotti Boys are the posterchildren for the guinea spike."

"He would have been attractive if not for that awful guinea spike."
guinea spike by ccarlisle May 27, 2006

Guinea Slide 

The act of sliding a car around a corner at high speed, similar to drifting, but usually performed by a Sicilian. Taking a corner at a high rate of speed in which the car slides around the corner so that it rights itself on the straight away.
I had to pull a Guinea Slide to get away from the cops the other night after leaving that job. We were hauling ass around the corner so I pulled the e brake and pulled a guinea slide onto Canal Street. Hah, Tokyo Drift, those asians rip off all the good stuff from us, it's a guinea slide.
Guinea Slide by Killin Sicilian October 21, 2010

Guinea Sub 

A sanwich high in saturated fats. Contains salami, capricola, pepperoni, mortadella, ect., ect. ect., aka. pig meat. Often eaten by guido's.
Man 1: Hey how about a guinea sub?
Man 2: sure, comin' right up. let me shave my body first.
Guinea Sub by Johnson Wayne March 14, 2010