De a jefe Share definition Flag Like a boss, or "fancily comfortable". Jefe means boss in spanish, this refers to something that is only allowed to bosses. Look at him on the jacuzzi, de a jefe! De a jefe by MexicanExpert May 29, 2018 0 0 Get merch Get the De a jefe mug. Buy Now — $32.95 See more merch