D.Pizzle Share definition Flag a real motha fucka. like one of dem dudes that comes to the 360 from his home of b-town. "yo man, cha boy david is the only d.pizzle keepin it fresh." D.Pizzle by d1228 March 12, 2008 0 0 Get merch Get the D.Pizzle mug. Buy Now — $32.95 See more merch