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An ego brain is someone that thinks they are the best thing in the world. They also belive they can do anything, at anytime, and anywhere. Also a word used in a system of a down song.
wow isnt jill a huge ego brain? yeah i heard she was.
Ego brain by TheNamesClay April 23, 2009

Brad Pitt ego 

A guy that thinks he looks like Brad Pitt instead of like nobody in particular.
The whining dork thought that guy had a Brad Pitt ego that's why she was really talking shit. She was the kind of person who would try to bite before you even got to do the obnoxious thing though, she was beyond vicious, someone you couldn't even stand being around.