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a 250's is a position that you perform in the action witch is know as anal sex. the way you perform this action you first must spin in a 250 degree turn then jump up once then slam that shit in her cuzo you know what im saying dawg.
ayo bro i just 250's that cucci last night my n word you know what it is dawg

hey grandma can i 250's that puss hole bitch
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F-250 syndrome 

When your girlfriend has a twin sister and you get confused and fuck their dad.
Bro, I pulled up to my girlfriend's house and I think I have F-250 syndrome
F-250 syndrome by FapPap July 20, 2021

250 strafe rei 

hits every single longjump you try
250 strafe rei by !!bunny July 27, 2020

250 sexual meaning 

When the male shits in the females asshole
Yo dog I kinda wanna* 250 sexual meaning *this bitch

250 Shuffle 

When a "friend" calls you and asks for a favor (money, pot, beer, etc,) with no intention of returning the favor. This person is always identified by the prefix 250 on their phone number in the greater Salt Lake City area (Magna)
Ring Ring: " The mailman didn't bring my welfare check today so could you borrow me money for Methadone?"

"Who was that?"

"Somebody playing the 250 Shuffle"
250 Shuffle by Walter Linwood October 10, 2007

250sonic 

A very rude name people can call each other which stands for being a 'thief', 'annoying' or 'overtly horny'.
A person who identifies as a 14 year old, but likely isn't, and also knows way too much for their age; has unrestricted internet access and uses it for the wrong reasons.
"Hey! You act like 250sonic!"
"Never say that again. That's too far man."
"..Maybe you're right."
250sonic by panoraxe February 6, 2025

sans sheriff 

Lawless use of fonts or typography, with no regard to aesthetics or legibility
I'm putting this CV straight in the bin. Written totally sans sheriff.
sans sheriff by Jamarley July 3, 2019