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.500 Smith 

The most powerful handgun cartridge on the market right now. Yes it beats the Desert Eagle's .50AE and Raging Bull's .454 Casull. This monster is 12.7 X 41mm (read: it's huge). In comparison, the cartridge you stick in AK-47s is 7.62 X 39mm and M16s use 5.56 X 45mm (interesting to note that .500 actually produces more muzzle energy than 5.56 NATO; however, because the barrel is shorter the energy drops off faster)... The gun you stick this bad boy in weighs close to 5 pounds loaded and is a complete beast. Basically, you shoot something with this, it dies.
I brought down an African Elephant in 1 shot with my shiny new .500 Smith and Wesson.
.500 Smith by gun enthusiast August 11, 2007
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.500 Smith 

a word used to express the caliber of .500 Smith&Wesson revolver. This revolver is so huge(the cartridge is like the size of your thumb!)it only carries 5 rounds rather than the traditional 6. This thing is used for stuff like killing grizzlies, I cant imagine what it could do to a person. This thing is more powerful than a .50AE desert eagle.
The hiker was being charged by a massive grizzly, so he killed it with his .500 Smith.
.500 Smith by !THOR September 5, 2008

smith & wesson 500 

Most powerful handgun ever made,even more punch than a desert eagle chambered for 50 AE. The S&W 500 fires 50 cal magnum rounds.
Hey little Billy want to shoot the most powerful handgun ever called the Smith & Wesson 500

smith & wesson .500 

the only handgun that you can stand behind someone and still get wind from a .50 cal. bullet. most powerful handgun on earth.
friend: tom just shot the smith & wesson .500! *jizz*
me: man have his balls dropped