C. diff 

aka clostridium difficile

A species of Gram-positive bacteria of the genus Clostridium that causes diarrhea and other intestinal disease when competing bacteria are wiped out by antibiotics.

I took Cipro for an ear infection and now I have C. diff. Should I sue the doctor or the pharmaceutical company?

C. diff by advocate4health April 4, 2010

Jett Diff 

The differentiation in the ability to play the Agent, Jett, In Riot's Valorant.

-"How did she win that fight?!"

-"Jett Diff"

Jett Diff by Tactical Waffles June 21, 2021

robbie diff 

an individual who disregards all social norms and behaviours that are considered by the majority to be acceptable, respectable or appropriate; while demonstrating an exceptional tolerance to alcohol consumption and educating the masses on the numerous and unique ways that the C-Bomb can be inserted into a conversation

i pulled a robbie diff last night

robbie diff by james.g.j.brown May 21, 2011

jiffy diff

When a certain person masterbates to a anime doll

Aw mom how many times did I tell you to knock before you walk in! I was doing the jiffy diff

jiffy diff by Jiffydiffer January 29, 2018

JGL DIFF

When ever you are losing lane in League of Legends. its never your fault its always JGL DIFF. Did you get solo killed 10 times in 12 min JGL DIFF. Is your laner 1v9 because you where afk for 15 min JGL DIFF

JAX: JGL DIFF ff 15
NOCTURNE: Kill yourself

JGL DIFF by Jonni dock April 2, 2023

SHIT THE DIFF 

When something or somebody has an accident or breaks something or breaks down mentally and/or physically.

Jim has finally shit the diff and is in hospital in recovery

SHIT THE DIFF by EXLER December 26, 2015

Shat the Diff 

A catastrophic failure of a car's transmission in which the differential collapses damaging the transmission and the vehicle loses drive , also leaving a trail of oil where it's been

i couldn't pick up droo, fash and professor layton as me astra had broke down, it shat the diff and left a trail of oil like the amoco cadiz along the road, darn diff!

Shat the Diff by davethejag February 5, 2009