When you are a fairly attractive person but you can't seem to maintain a relationship regardless of how attractive you are.
SUE: My boyfriend broke up with me. I thought we had a great relationship. I don't understand why I can't manage to stay in a good relationship.
LORI: Girl...you got Jennifer Aniston Syndrome.
LORI: Girl...you got Jennifer Aniston Syndrome.
by not4uboy August 20, 2010

by Tris Penkal October 23, 2006

by sweaty sock sally April 30, 2012

She is perfection. Every room she walks into she fills it with light, joy, and happiness. Her smile is everything <3
by Annie Mclaine October 21, 2020

by Alex’s Bitch September 23, 2020

Jennifer Aniston (born February 11, 1969) is an Emmy and Golden Globe Award-winning American film and television actress, best known for her role as Rachel Green in the popular television sitcom Friends. Since Friends she has starred in several successful Hollywood films, including Bruce Almighty, Along Came Polly and The Break-Up.
For the last three years a victim of lunatic Holy Jolie fans from a gossip blog.
Beautiful, talented and smart, she causes Brangaloonies to convulse.
For the last three years a victim of lunatic Holy Jolie fans from a gossip blog.
Beautiful, talented and smart, she causes Brangaloonies to convulse.
At the mention of Jennifer Anistons name, the Brangaloon stuck her thumb in her mouth, dropped to the floor and started screaming.
by NotaLoon September 25, 2007

A compliment one pays to his wife or girlfriend, especially as they approach a more mature age. Meaning she is as hot if not hotter than Jennifer Aniston (circa: Just Go With It bikini scene)
by FWB4D November 21, 2022
