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Either to:
1. Fuck a girl while walking somewhere
2. Fuck a random girl on the way to her house
3. Fuck a girl so hard it takes an hour for the cum to leak back out
Johnny was giving Mary a homerun on the way back from the bar.
Homerun by Harry Toba February 3, 2014

Homofungalopogus 

A homosexual man or woman who have a mad amount of shrooms and other fucked up fungi growing on his/her face, Oh and they are half Platypus.
Hey look it's a Homofungalopogus Timmy.

homerun bitch 

A chick you meet on the first night that goes all the way with you can be for a one night stand or longer
Nick is a total bad ass he found a homerun bitch last night at the club.
homerun bitch by snconnection September 7, 2013
A term in 'League of Legends' which is used as a word to describe a mini-game within the gamemode of 'ARAM'. The game is to buy the fastest items in the shop and try and make it to the enemy nexus before dying. People usually add their own spins to the game to make it more fun.
Let's play some homerun after this ARAM match!
Homerun by Dean Gray August 10, 2014

Nick Homerun

A homerun that barely makes it over the fence. Originated by Nick Giordano since all of his homeruns barely made it over the fence.
Jeff: Yo! I went yard on that one!

Eric: What are you talking about? It was clearly a Nick Homerun.
Nick Homerun by gpc March 11, 2008

inside the park homerun

Masturbating or because of the inability to get a girl in bed masturbate instead
Guy1: Has Ron ever gotten around the bases

Guy2: No but he hits inside the park homeruns everyday