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Buffalo Bill 

Cross-dressing transexual. As seen in "Silence of the Lambs" film and also mocked in "American Pie 3: The Wedding". A Buffalo Bill is a guy who wants to have a sex change and looks like a girl.
"It put the dress in the drawers" or "It rubs the lotion on the skin unless it wants the hose again".
Buffalo Bill by George May 13, 2005
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buffalo horn 

A man who has not shaved his pubic hairs in over 4.5 mounths (the horn represents the male's penis)
"Holy crap man when the last time you shaved down south?"

"it's been around 5 mounths"

"haha you've got a buffalo horn"
buffalo horn by purp forty four December 29, 2009
Verb - to push ahead, plow over or unwittingly dominate in one's actions or in a given situation.
Noun - Someone who embodies these qualities.
Stop buffaloing through my twelve-pack and buy your own.

Buffalo by August O. November 24, 2006

Buffalo ny 

The only place where people think about pussy, dick, and sex thats why this city is overpopulated. You can be a hot guy here and you will be ignored like me this city sucks and is a snooze fest of the shitty buffalo bills everybody here smokes weed. Theres to many assholes, ignorant and arrogant people here also litterbugs. Lot of weirdos bums and homeless drug addicts live here. If i had the money i would move from this shitty city the weather sucks here just like the people. Never come to this city it blows horse dick.
Buffalo ny sucks dont visit this city
Buffalo ny by Furry2011 June 30, 2021
Buffalo is a city in upstate New York that has something for everyone: shopping, partying, parks, people, art festivals, snow in the winter, beautiful seasons, architectural treasures, restaurants of every kind, and affordable housing. We have our share of crooked politicians, but, hey, tell me some place that does not?
Come on over to the city of good neighbors and we'll show you around!
buffalo by Medea June 27, 2005

University at Buffalo 

A well respected University in the city of Buffalo, New York. UB is a flagship of the State University of New York system and is over 165 years old. The school offers some of the nations best degrees in Business, Architecture, Medicine, Dentistry, engineering, physics, education, and social sciences, to name a few. UB's athletic teams play in the Mid American Conference and are an FBS, Division 1 program. The athletic teams are known as the "Bulls", while the schools mascot is "Victor E. Bull". UB comprises roughly 20,000 undergraduates and about 10,000 graduate students. It is the largest university in the Northeast (comprising New England and New York State). Despite the other definition, UB is in fact a prestigious university and is one of the hardest schools to be accepted into in the state of New York. It also has lower admission rates than many competing flagship public schools in the nation.
Person 1: Man I wish I went to the University at Buffalo...they have athletics, well respected programs, and an awesome college experience...too bad I'll be going to a private school that costs $56,000

Person 2: Yeah, well I go to the University at Buffalo...and by the time we both graduate, we'll be making the same amount of money...except you'll be in $200,000 of debt.

Person 3: *sigh*
A city on the western tip of New York State, which once upon a time boasted a population and commerce only second to New York but now is only known for failing sports' franchises and a law enforcement system where no one, from minorities to 75-year-old men, is safe from brutality.
You're going to Buffalo? You better be careful, there's nothing but chicken wings and cops ready to bust the heads of grandpas in!

Buffalo, known as the "city of good neighbors" by its inhabitants, is now known by the rest of the country for its police department's missteps when it comes to allowing citizens to assemble and practice their first amendment rights.
Buffalo by jes nemo June 7, 2020