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When a guy says it it is referred to being uncool

Guy 1: Dude let's go to this wicked house party!
Guy 2: no that sounds like a bad thing...
Guy 1: Dude you're so lame.

When a girl says it to a guy it is used in a cute way to joke around or be flirty

Guy: You're so cute when you make stupid jokes
Girl: Omg shut up Lol you're so lame, my jokes are funny. Lol you're lame. Lol
Lame by selfiequeen June 11, 2014
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A characteristic exhibited by persons who are boring, unadventerous, and prone to censoring the expresions of others.
Wow, those UrbanDictionary.com editors sure are lame, they wouldn't even post my awesome definition of uga!
lame by Donny September 2, 2005
Related Words
word to describe the most boring, annoying, odd, weird, uninteresting, tiresome, unexciting, spiritless human that has ever walked this planet.
Tyler D. is lame, he is so lame he's in a social club.
Lame by TheLamest101 March 2, 2015
(Adj)
1. Someone who shields themselves from fun too often. Esp. when rejecting propositions for weak reasons.
Person 1: Hey, wanna go to that new club?
Person 2: No thanks, I have a project I need to get started.
Person 1: Don't be lame, you can work on it tomorrow.
Lame by Snesdude October 10, 2012
Noun: A responsible homebody, introvert, who is content with work, and domestic life. Someone who likes to stay home and rather than go out and act a fool or spend wrecklessly.

Adjective: Descriptive if said qualities in a person.
Babe, you're such a lame, and that is why I love being with you.

He's so lame.
Lame by Bekkiwiththegoodhair December 18, 2017
An expression used to cut people off when they are talking about something uninteresting or you just feel like being a douche.
- Hey dude I just got this--
-LAME!
- I just got--
-LAME!
-Sto--
-LAME!
-*cries then commits suicide*
LAME! by FISHYFOO February 14, 2010
loser, dweeb, nerd, Chukez, lamonhead, waka-flaka-lame, anyone who is out of touch and socially awkward.
Yo that kid Jahmar is so lame, he has no steez whatsoever.
Lame by Chukes January 2, 2011