D.U.F.F.

1. Dumb Ugly Fat Fuck
2. Designated Ugly Fat Friend (the less harsh defintion)

That we-gotta-go-girl is such a D.U.F.F.

by cchriss92 August 3, 2007

D-U-F-F

Dumb Ugly Fat Friend

have u met my new D-U-F-F

by Drapp April 14, 2015

D.T.F.F.

Down to fuck females.

Skanks I'm D.T.F.F. in dis biotch.

by skankyskankyho May 25, 2010

D.U.F.F.

D-dumb
U-ugly
F-fat
F-friend

or

D-dumb
U-unreasonable
F-fuck
F-face

Go with it as you wish.

Snooki: "Oh my God. What a D.U.F.F.!"
Deena: "I know, right? Totally a duff."

by Smigslovesyou101 April 13, 2011

D.U.F.F.

Designated Ugly Fat Friend. If you know of a DUFF, You are a DUFF, or you've heard of a DUFF, you are in luck. Because I hate to break it to you but you are a DUFF. You don't have to be fat or ugly to be a DUFF. DUFF is just a catch for a person who doesn't fit in. If you ever felt left out, excluded, or just different it means you were a DUFF and potentially are one now. But don't worry. Being a DUFF is a good thing. It means you are an original person. SO pump your fist in the air if you're a DUFF!

Tyler is a D.U.F.F.

by ThtYllwBch June 9, 2015

D.U.F.F.

Dumb Ugly Fat Friend.

Damn that bitch is a D.U.F.F. Damn your sister's hot, and who's the DUFF?

by Pwat May 2, 2006

D-U-F-F

Dumb Ugly Fat Friend

have u met my new D-U-F-F

by Drapp April 14, 2015