Someone who temporarily behaves as though he or she has cream filling for brains. Can be derogatory or just an observation.
1. She ran out into traffic? What a twinkie-head!
2, That twinkie-head cat won't come out of the tree.
2, That twinkie-head cat won't come out of the tree.
by nilochlainn April 1, 2009

by Fish Affair October 5, 2017

by redlobsterfan8849 July 23, 2021

Darla got her nickname giving blowjobs for twinkies and a twelve pack of pepsi hence the word 'twinkie twelvepack'.
by princessfukella September 5, 2009

by TheBiggestNiggaTwinkie May 1, 2015

A drug user who gains pride and purpose from taking a wide assortment of drugs, especially the endless variations of tryptamines and phenethylamines. Drug Twinkies generally view their drug use as profound mental exploration, and will harp on comparing the different psychonautic possibilities of various drugs.
by backfisch December 26, 2004

Juliana Ireland Jammerz and Zayla Lenay Houston.
Also known as, awesome hardcore best friends who are lazy.
Also known as, awesome hardcore best friends who are lazy.
"OH MY GOSH! LOOK AT THOSE TWINKIES! I WISH I WAS AS COOL AS THEM!"
"Those girls are such freakin' twinkies "
You can also use it as adjective
"GIMME A TWINKIE HUG, FOOOOOL!"
"Those girls are such freakin' twinkies "
You can also use it as adjective
"GIMME A TWINKIE HUG, FOOOOOL!"
by Zayla March 30, 2009
