Someone who temporarily behaves as though he or she has cream filling for brains. Can be derogatory or just an observation.
1. She ran out into traffic? What a twinkie-head!
2, That twinkie-head cat won't come out of the tree.
One socially-permissible way of NOT swearing or threatening to commit a felony while meaning to say things like "my life is fucking over because of that," "I want to kill her but I can't" and similar such. It's an excellent reply to any unfavorable situation, denoting momentary acceptance in the face of insurmountable odds.
The bank LOST my money? (deep breath) Hey, it is what it is.